PUBLICATIONS
37. Positioning of nucleosomes containing γ-H2AX precedes active DNA demethylation and transcription initiation.
doi: https://doi.org/10.1101/2020.03.06.980912. Preprint at bioRxiv and under consideration at Nat Commun; 2020;
Dobersch S, Rubio R, Singh I, Günther S, Graumann J, Cordero J, Castillo-Negrete R, Huynh MB, Mehta A, Braubach P, Cabrera-Fuentes H, Jürgen Bernhagen J, Chao CM, Bellusci S, Günther A, Preissner KT, Dobreva G, Wygrecka M, Braun T, Papy-Garcia D and Barreto G.
36. Recognition of breathprints of lung cancer and chronic obstructive pulmonary disease using the Aeonose®electronic nose.
J Breath Res; 2020; Manuscript accepted.
Krauss E, Haberer J, Barreto G, Degen M, Seeger W and Guenther A.
35. Failure to Down-Regulate miR-154 Expression in Early Postnatal Mouse Lung Epithelium Suppresses Alveologenesis, with Changes in Tgf-β Signaling Similar to those Induced by Exposure to Hyperoxia.
Cells. 2020 Apr 2;9(4). pii: E859. doi: 10.3390/cells9040859
Chao CM, Carraro G, Rako ZA, Kolck J, Sedighi J, Zimmermann V, Moiseenko A, Wilhelm J, Young BM, Chong L, Wu J, Contreras A, Minoo P, Barreto G, Warburton D and Bellusci S.
34. Non-coding RNAs and nuclear architecture during epithelial-mesenchymal transition in lung cancer and idiopathic pulmonary fibrosis.
Cell Signal; 2020 Jun;70:109593. doi: 10.1016/j.cellsig.2020.109593. Epub 2020 Mar 2
Rubio K, Castillo-Negrete R and Barreto G.
33. Loss of LRP1 promotes acquisition of contractile-myofibroblast phenotype and release of active TGF-β1 from ECM stores.
Matrix Biol; doi: 10.1016/j.matbio.2019.12.001
Schnieder J, Mamazhakypov A, Birnhuber A, Wilhelm J, Kwapiszewska G, Ruppert C, Markart P, Wujak L, Rubio K, Barreto G, Schaefer L and Wygrecka M.
32. Exploring the Ability of Electronic Nose Technology to Recognize Interstitial Lung Diseases (ILD) by Non-Invasive Breath Screening of Exhaled Volatile Compounds (VOC): A Pilot Study from the European IPF Registry (eurIPFreg) and Biobank.
J Clin Med; 2019 Oct 16;8(10). pii: E1698. doi: 10.3390/jcm8101698
Krauss E, Haberer J, Maurer O, Barreto G, Drakopanagiotakis F, Degen M, Seeger W and Guenther A.
31. Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in Idiopathic Pulmonary Fibrosis.
Nat Commun; 2019; May 20;10(1):2229. doi: 10.1038/s41467-019-10066-7
Rubio K, Singh I, Dobersch S, Sarvari P, Günther S, Cordero J, Mehta A, Wujak L, Cabreras-Fuentes H, Chao CH, Bellusci S, Günther A, Dobreva G, Wygrecka M, Seeger W, Preissner KT, Savai R, Papy-Garcia D, Heikenwalder M, Pullamsetti SS, Braun T and Barreto G.
30. Pioneering function of Isl1 in epigenetic control of cardiomyocyte cell fate.
Cell Research; 2019; Apr 25. doi: 10.1038/s41422-019-0168-1
Cheedipudi S, Liang X, Gao R, Zhang Q, Cordero J, Caputo L, Günther S, Kuenne C, Bhattacharya S, Yuan X, Barreto G, Chen Y, Braun T, Evans SM, Sun Y and Dobreva G.
29. Lamin B1 loss drives lung cancer development and metastasis by epigenetic derepression of RET proto-oncogene.
J Exp Med; 2019; Apr 23. pii: jem.20181394. doi: 10.1084/jem.20181394
Jia Y, Vong JS, Asafova AS, Garvalov BK, Caputo L, Cordero J, Boettger T, Günther S, Fink L, Acker T, Barreto G, Seeger W, Braun T, Savai R and Dobreva G.
28. Pioneer factors and architectural proteins mediating embryonic expression signatures in cancer.
Trends Mol Med; 2019; Feb 19. pii: S1471-4914(19)30019-X. doi: 10.1016/j.molmed.2019.01.008
Dobersch S, Rubio K and Barreto G.
27. Functional interactions between scaffold proteins, non-coding RNAs and genome loci induce liquid-liquid phase separation as organizing principle for three-dimensional nuclear architecture. Implications in cancer.
FASEB J; 2019; Feb 11:fj201802715R. doi: 10.1096/fj.201802715R.
Rubio K, Dobersch S and Barreto G.
26. A critical role for miR-142 in alveolar epithelial lineage formation.
Cell. Mol. Life Sci.; 2019; Mar 18. doi: 10.1007/s00018-019-03067-8
Shrestha A, Carraro G, Nottet N, Vasquez-Armendariz AI, Herold S, Cordero J, Singh I, Wilhelm J, Barreto G, Morty R, El Agha E, Mari B, Chen C, Zhang JS, Chao CM and Bellusci S.
25. Impact of Fgf10 deficiency on pulmonary vasculature formation in a mouse model of bronchopulmonary dysplasia.
Hum Mol Genet; 2018; Dec 19. doi: 10.1093/hmg/ddy439
Chao CM, Moiseenko A, Kosanovic D, El Agha E, Wilhelm J, Kampschulte M, Yahya F, Ehrhardt H, Zimmer KP, Barreto G, Rizvanov A, Morty RE, Rottier RJ, Zhang JS and Bellusci S.
24. MiCEE is a ncRNA-protein complex that mediates epigenetic silencing and nucleolus organization.
Nat Genet; 2018; doi: 10.1038/s41588-018-0139-3. Epub ahead of print
Singh I, Contreras A, Cordero J, Rubio K, Dobersch S, Günther S, Jeratsch S, Mehta A, Krüger M, Graumann J, Seeger W, Dobreva G, Braun T and Barreto G.
23. Non-invasive lung cancer diagnosis by detection of GATA6 and NKX2-1 isoforms in exhaled breath condensate.
EMBO Mol Med; 2016; 8, 1380-1389, doi:10.15252/emmm.201606382
Mehta A, Cordero J, Dobersch S, Romero-Olmedo AJ, Savai R, Bodner J, Chao CM, Fink L, Guzmán-Díaz E, Singh I, Dobreva G, Rapp UR, Günther S, Ilinskaya ON, Bellusci S, Dammann RH, Braun T, Seeger W, Gattenlöhner S, Tresch A, Günther A and Barreto G.
22. Direct inhibition of oncogenic KRAS by Bacillus pumilus ribonuclease (binase).
BBA-Mol Cell Res; 2016 Jul;1863(7 Pt A):1559-67
Ilinskaya ON, Singh I, Dudkina E, Ulyanova V, Kayumov A and Barreto G.
21. Fgf10 deficiency is causative for lethality in a mouse model of bronchopulmonary dysplasia.
J Pathol; 2016 Oct 22. doi: 10.1002/path. 4834
Chao CM, Yahya F, Moiseenko A, Tiozzo C, Shrestha A, Ahmadvand N, El Agha E, Quantius J, Dilai S, Kheirollahi V, Jones M, Wilhem J, Carraro G, Ehrhardt H, Zimmer KP, Barreto G, Ahlbrecht K, Morty RE, Herold S, Abellar RG, Seeger W, Schermuly R, Zhang JS, Minoo P and Bellusci S
20. High Mobility Group protein mediated transcription requires DNA damage marker γ-H2AX.
Cell Research; 2015 Jul;25(7):837-50
Singh I, Ozturk N, Mehta A, Cordero J, Hasan D, Cosentino C, Sebastian C, Krüger M, Looso M, Carraro G, Bellusci S, Seeger W, Braun T, Mostoslavsky R and Barreto G.
19. Epigenetics in lung cancer diagnosis and therapy.
Cancer Metast Rev; 2015 Jun;34(2):229-41
Mehta A, Dobersch S, Romero-Olmedo AJ and Barreto G.
18. Validation of Tuba1a as appropriate internal control for normalization of gene expression analysis during mouse lung development.
Int. J. Mol. Sci; 2015 Feb 25;16(3):4492-511
Mehta A, Dobersch S, Dammann RH, Bellusci S, Ilinskaya ON, Braun T and Barreto G.
17. Generation and validation of miR-142 knock out mice.
PLoS One; 2015 Sep 1;10(9):e0136913
Shrestha A, Carraro G, El Agha E, Mukhametshina R, Chao CH, Rizvanov A, Barreto G and Bellusci S.
16. Hmga2 is required for canonical WNT signaling during lung development.
BMC Biol; 2014 Mar 24;12:21
Singh I, Mehta A, Contreras A, Boettger T, Carraro G, Wheeler M, Cabrera-Fuentes HA, Bellusci S, Seeger W, Braun T and Barreto G.
15. HMGA proteins as modulators of chromatin structure during transcriptional activation.
Front Cell Dev BiolFront Cell Dev Biol; 2014 Mar 6;2:5
Ozturk N, Singh I, Mehta A, Braun T and Barreto G
14. Cyclospora cayetanensis: this emerging protozoan pathogen in Mexico.
Am J Trop Med Hyg; 2014 Feb;90(2):351-3
Sánchez-Vega JT, Cabrera-Fuentes HA, Romero-Olmedo AJ, Ortiz-Frías JL, Sokolina F and Barreto G.
13. miR-142-3p balances proliferation and differentiation of mesenchymal cells during lung development.
Development ; 2014 Mar;141(6):1272-81
Carraro G, Shrestha A, Rostkovius J, Contreras A, Chao CM, El Agha E, Mackenzie B, Dilai S, Guidolin D, Taketo MM, Günther A, Kumar ME, Seeger W, De Langhe S, Barreto G and Bellusci S.
12. RNase1 prevents the damaging interplay between extracellular RNA and tumour necrosis factor-α in cardiac ischaemia/reperfusion injury.
Thromb Haemost; 2014 Dec;112(6):1110-9
Cabrera-Fuentes HA, Ruiz-Meana M, Simsekyilmaz S, Kostin S, Inserte J, Saffarzadeh M, Galuska SP, Vijayan V, Barba I, Barreto G, Fischer S, Lochnit G, Ilinskaya ON, Baumgart-Vogt E, Böning A, Lecour S, Hausenloy DJ, Liehn EA, Garcia-Dorado D, Schlüter KD and Preissner KT.
11. Quantitative Proteome Analysis of Alveolar Type-II Cells Reveals a Connection of Integrin Receptor Subunits Beta 2/6 and WNT Signaling.
J Proteome Res; 2013 Dec 6;12(12):5598-608
Mukhametshina RT, Ruhs A, Singh I, Hasan D, Contreras A, Mehta A, Nikam VS, Ahlbrecht K, Carraro G, Cabrera-Fuentes HA, Jiang D, Voswinckel R, Seeger W, Bellusci S, Scharffetter-Kochanek K, Bagaeva TV, Preissner KT, Boettger T, Braun T, Krüger M and Barreto G.
10. Transient Inhibition of FGFR2b-Ligands Signaling Leads to Irreversible Loss of Cellular β-Catenin Organization and Signaling in AER during Mouse Limb Development.
PLoS One; 2013 Oct 22;8(10):e7624
Danopoulos S, Parsa S, Al Alam D, Tabatabai R, Baptista S, Tiozzo C, Carraro G, Wheeler M, Barreto G, Braun T, Li X, Hajihosseini MK and Bellusci S.
9. Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones.
PLoS One ; 2012;7(2):e32366
Saffarzadeh M, Juenemann C, Queisser MA, Lochnit G, Barreto G, Galuska SP, Lohmeyer J and Preissner KT
8. Gemcitabine functions
epigenetically by inhibiting repair mediated DNA demethylation.
PLoS One; 2010 Nov 19;5(11):e14060
Schäfer A, Schomacher L, Barreto G, Döderlein G and Niehrs C
7. Gadd45a promotes epigenetic gene activation by repair mediated DNA demethylation.
Nature; 2007 Feb 8;445(7128):671-5
Barreto G, Schäfer A, Marhold J, Stach D, Swaminathan SK, Handa V, Döderlein G, Maltry N, Wu W, Lyko F and Niehrs C.
6. Nuclear reprogramming of human somatic cells by xenopus egg extract requires BRG1.
Curr Biol; 2004 Aug 24;14(16):1475-8
Hansis C, Barreto G, Maltry N and Niehrs C.
5. The germ cell nuclear factor is required for retinoic acid signaling during Xenopus development.
Mech Dev; 2003 Apr;120(4):415-28
Barreto G, Borgmeyer U and Dreyer C.
4. The function of Xenopus germ cell nuclear factor (xGCNF) in morphogenetic movements during neurulation.
Dev Biol; 2003 May 15;257(2):329-4
Barreto G, Reintsch W, Kaufmann C and Dreyer C.
3. Oocytes and embryos of Xenopus laevis express two different isoforms of germ cell nuclear factor (GCNF, NR6A1).
Mech Dev; 2002 Oct; 118(1-2):261-4
Schohl A, Barreto G, Joos T and Dreyer C.
2. Interaction of S-adenosylhomocysteine hydrolase of Xenopus laevis with mRNA(guanine-7-)methyltransferase: implication on its nuclear compartmentalisation and on cap methylation of hnRNA.
Biochim Biophys Acta; 2002 Jun 12;1590(1-3):93-10
Radomski N, Barreto G, Kaufmann C, Yokoska J, Mizumoto K and Dreyer C.
1. Transcriptional repression by the insulator protein CTCF involves histone deacetylases.
Nucleic Acids Res; 2000 Apr 15;28(8):1707-13
Lutz M, Burke LJ, Barreto G, Goeman F, Greb H, Arnold R, Schultheiss H, Brehm A, Kouzarides T, Lobanenkov V and Renkawitz R.
Director of Scientific Projects and Research Group Leader